Assessment of Sensitivity and Specificity of Patient-Collected Lower Nasal Specimens for Severe Acute Respiratory Syndrome

This prognostic study compared collection of three specimens: a patient-collected lower nasal swab, a physician-collected lower nasal swab and a physician-collected oropharyngeal swab from 30 participants infected with SARS-CoV-2. Diagnostic equivalence was seen across the three methods of specimen collection. While it was discussed that the small sample size limits generalizability, self-collected lower nasal swabs … Read more

Evaluation of a novel anterior nasal swab for the detection of SARS-CoV-2

This study investigated a novel anterior nasal swab Rhinoswab™ which is designed to standardise self-collection, maximise sample uptake and improve user comfort. Combined throat and nose swabs and neat saliva samples were used as comparators. The overall positive percentage agreement between the Rhinoswab and the combined throat and nose swab was 95.2 % at day 2 … Read more

Mass surveillance of SARS-COV-2 utilising self-collection swabs and high throughput laboratory techniques: An Australian case study of asymptomatic Year 12 students at the Qudos Bank Arena

A total of 15,519 participant performed self-collection of a novel nasal swab (Rhinoswab). They were subsequently tested on a mobile laboratory platform combining a liquid handler (Myra) with a thermocycler (micPCR) and SARS-CoV-2 RT-PCR reagents. Roche Liat was implemented as a confirmation device. A survey of 2,533 participants revealed: 91% found self-collection easy to perform. … Read more

Swabs Collected by Patients or Health Care Workers for SARS-CoV-2 Testing

A cross sectional study with 530 participants from five ambulatory clinics comparing self-collected tongue, nasal and mid turbinate  samples with clinician collected nasopharyngeal samples. All samples were submitted to a reference laboratory for reverse-transcriptase–polymerase-chain-reaction (RT-PCR) testing that yielded qualitative results (positive or negative) and cycle threshold (Ct) values for positive samples only. Both the nasal and mid-turbinate … Read more

Self-collection: An appropriate alternative during the SARS-CoV-2 pandemic

A prospective study of 236 patients comparing patient collected throat and nasal swabs, clinician collected (HCW)  throat and nasal swabs and clinician collected throat and nasopharyngeal swabs. Samples were analysed for SARS-CoV-2 as well as common respiratory viruses. Self-collection was highly concordant with HCW collected for all viruses including SARS-CoV-2 and the mean SARS-CoV-2 E-gene … Read more

Comparison of Unsupervised Home Self-collected Midnasal Swabs With Clinician-Collected Nasopharyngeal Swabs for Detection

A cross sectional study with 185 symptomatic patients, of which 41 had positive results. Study participants were recruited from symptomatic outpatients’ health care workers presenting to drive-through clinics. Participants were provided test kits for unsupervised home self-collection of a mid-nasal swab. Home swab performance was compared with clinician-collected nasopharyngeal swabs, which were collected by medical … Read more

Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing: a systematic review and meta-analysis

A search of PubMed, Embase, MEDLINE, Web of Science, medRxiv, bioRxiv, SSRN, and Research Square from Jan 1, 2000, to Nov 16, 2020 was conducted. Original clinical studies that examined the performance of nasopharyngeal swabs and any additional respiratory specimens for the diagnosis of SARS-CoV-2 infection among individuals presenting in ambulatory care were include in the review. … Read more

Evaluation of Rhinomed Rhinoswab (Hydrophobic Flock) Elution Efficiency

An independent laboratory, Gnomix (Adelaide, Australia) was engaged to compare the elution efficiency of the Rhinoswab compared to the standard of care nasal swab (Copan ESwab™). Method An aliquot of gamma-irradiated (inactivated) SARS-CoV-2 virus with a nominal CT value of 18 (assay dependent) was diluted 1/200 in a stock solution of donated saliva to represent … Read more

Rhinoswab Sample Capture Study

The objective of the nasal swab yield study was to compare the mean sample capture performance of the rhinoswab against the commercially available standard of care nasal swab (Copan ESwab™) at various insertion time points. Design An comparative experiment to measure the absorption profile of Rhinoswab when worn in the nose for different time periods … Read more